The reference site for Basiliximab

Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants.

WHAT IS Basiliximab?

Basiliximab belongs to a group of medicines known as immunosuppressive agents. It is used to lower the body’s natural immunity in patients who receive kidney transplants.
When a patient receives a kidney transplant, the body’s white blood cells will try to get rid of (reject) the transplanted kidney. This medicine works by preventing the white blood cells from getting rid of the transplanted kidney. The effect of this medicine on the white blood cells may also reduce the body’s ability to fight infections.

 

Brand Name(s): Simulect
CAS nº: 152923-56-3
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Product Info

The sections below will provide you with more specific information and guidelines related to basiliximab and its correct use. Please read them carefully.

FDA Information

Basiliximab was approved by the FDA in 1998. A prescription is required for this medicine.
Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Basiliximab belongs to a group of medicines known as immunosuppressive agents. It is used to lower the body’s natural immunity in patients who receive kidney transplants.
When a patient receives a kidney transplant, the body’s white blood cells will try to get rid of (reject) the transplanted kidney. This medicine works by preventing the white blood cells from getting rid of the transplanted kidney.
The effect of this medicine on the white blood cells may also reduce the body’s ability to fight infections.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Administer basiliximab directly into a vein (IV), or use as directed by your doctor. This medication is usually given in two doses: the first dose is given within two hours prior to transplant surgery and the second dose is given four days after surgery.

This medication is also used in addition to other medications (e.g., cyclosporine, corticosteroids) to prevent rejection of transplanted organs. Take all medications exactly as prescribed by your doctor. If you have any questions, please ask your doctor or pharmacist to explain them to you.

Furthermore, follow all instructions for proper mixing and dilution with correct IV fluids. When mixing the diluted solution, gently invert the bag to avoid foaming and do not shake. If required, ask your pharmacist if you have questions regarding the use of this medication.

Before using this product, check visually for particles or discoloration. If either is present, do not use the liquid.

What special precautions should I follow?

BEFORE TAKING BASILIXIMAB:
Tell your doctor your medical history, especially if you have any allergies, as well as all prescription and non-prescription drugs you may be using.

This drug may make you dizzy. Use cautiously when engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages because they can intensify the dizziness effect of this medication.

If for any reason you have stopped taking basiliximab and you need to restart this medication, you have a high chance of developing an allergic reaction. It is important that you know the symptoms of this allergic reaction (see side effects section). Please consult your doctor or pharmacist before restarting basiliximab, and be sure you have easy access to medical care if you are restarting treatment.

The use of medications that affect the immune system may lead to increased risk of infection or certain types of cancer. Notify your doctor promptly if you experience fever, weakness, swollen glands, night sweats, unusual lumps, or any new symptoms.

Women of childbearing potential should use effective birth control before beginning therapy with this drug, during the use of this drug, and for two months after finishing therapy with this drug. Consult your doctor or pharmacist for more information.
Furthermore, this medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

Additionally, it is not known if this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.

What should I do if I forget a dose?

If you miss a dose, contact your doctor or pharmacist immediately.

What side effects can this medication cause?

Along with its needed effects, a medicine may cause some unwanted symptoms. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
More common

Abdominal pain; back pain; coughing; dizziness; fever or chills; loss of energy or weakness; painful urination; shortness of breath; sore throat; swelling of the ankles, body, face, feet or lower legs; trembling or shaking of the hands or feet; vomiting; white patches in the mouth or throat or on the tongue.
Less common

Abnormal vision; agitation; anxiety; bleeding, tender, or enlarged gums; blood in the stool; bruising; chest pain; depression; difficulty in urinating; fatigue; itching; numbness or pain in the legs; skin rash; sores in the mouth; “stocking and gloves” sensation of the hands or feet; tingling.
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Check with your doctor if any of the following side effects continue or are bothersome:
More common

Acne; constipation; diarrhea; headache; heartburn; nausea; trouble in sleeping; weight gain.
Less common

Excessive hair growth; joint pain; muscle pain.
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor

What storage conditions are needed for this medicine?

Refrigerate vials between 36 and 46 degrees F (2 and 8 degrees C) away from light and moisture. Do not freeze.
After mixing and dilution in correct IV fluids (consult your pharmacist for details), the drug is stable at refrigerator temperature for 24 hours or at room temperature for 4 hours. It is important to discard any unused liquid.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. If the victim has collapsed or is not breathing, then call the local emergency services on 911.
Symptoms of overdose may include:
wheezing
    chest tightness
    fever
    itching
    bad cough
    blue skin color
    swelling of face, lips, tongue, or throat

 

Product Images

PICTURES OF BASILIXIMAB PILLS

Below you will find images and specific information on the principal types of basiliximab that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.
The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: SIMULECT®
Strength(s): 20 MG
Imprint: SIMULECT basiliximab
Manufacturer: NOVARTIS

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